Gene Therapy for Hereditary Hearing Loss Mutations in over 70 genes have now been identified as causing hereditary hearing loss in humans. This expanding knowledge about the genetics of hearing loss opens the door for the development of gene therapies aimed at restoring hearing function by delivering corrective DNA to the inner ears of patients with ... Article
Article  |   May 01, 2013
Gene Therapy for Hereditary Hearing Loss
Author Affiliations & Notes
  • Devin S. McDougald
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD
  • Lisa L. Cunningham
    National Institute on Deafness and Other Communication Disorders (NIDCD), National
  • Wade W. Chien
    Institutes of Health (NIH), and received funding for the work of this article from the NIDCD, Division of Intramural Research
  • Disclosure: Devin S. McDougald, Lisa L. Cunningham, and Wade W. Chien are employees of National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), and received funding for the work of this article from the NIDCD Division of Intramural Research.
    Disclosure: Devin S. McDougald, Lisa L. Cunningham, and Wade W. Chien are employees of National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), and received funding for the work of this article from the NIDCD Division of Intramural Research.×
Article Information
Hearing Disorders / Balance & Balance Disorders / Special Populations / Genetic & Congenital Disorders / Articles
Article   |   May 01, 2013
Gene Therapy for Hereditary Hearing Loss
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics, May 2013, Vol. 17, 5-14. doi:10.1044/hhd17.1.5
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics, May 2013, Vol. 17, 5-14. doi:10.1044/hhd17.1.5

Mutations in over 70 genes have now been identified as causing hereditary hearing loss in humans. This expanding knowledge about the genetics of hearing loss opens the door for the development of gene therapies aimed at restoring hearing function by delivering corrective DNA to the inner ears of patients with hearing loss caused by these mutations. This review summarizes some of the recent advances toward the goal of developing gene therapy as a treatment for hereditary hearing loss in humans.

Acknowledgments
The authors are grateful to Thomas B. Friedman, Tracy S. Fitzgerald, and Meghan C. Drummond for helpful comments on the manuscript. This work was funded by the NIDCD Division of Intramural Research.
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