Article  |   April 2011
Mechanisms of Cisplatin Ototoxicity and Routes for Intervention
Hearing Disorders
Article   |   April 2011
Mechanisms of Cisplatin Ototoxicity and Routes for Intervention
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics April 2011, Vol.15, 3-14. doi:10.1044/hhd15.1.3
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics April 2011, Vol.15, 3-14. doi:10.1044/hhd15.1.3

Cisplatin is a potent chemotherapy drug that is still used frequently in spite of its many toxic side effects, of which ototoxicity is among the most severe. Modern research has provided new insights into the biological mechanisms of cisplatin-induced cochlear damage and has opened new avenues for co-treatments to potentially reduce or eliminate the ototoxicity. As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. The current review begins with a description of cisplatin ototoxicity and its mechanisms. Interventions that target a reduction of oxidative stress or intercession in the apoptotic cell death pathway as a means of limiting cisplatin-induced hearing loss are then discussed in the second half of the review.

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