Mechanisms of Ototoxicity The last century witnessed the unparalleled discovery of pharmacologic agents with both life-saving and quality-enhancing effects. Despite such virtues, the use of these agents also entails the possibility of adverse effects and inner ear (or “oto”) toxicity represents one of these potential complications. Understanding the mechanisms of ototoxicity has ... Article
Article  |   September 01, 2005
Mechanisms of Ototoxicity
Author Affiliations & Notes
  • Gale Tuper
    Department of Otolaryngology-Head & Neck Surgery, Henry Ford Health System, Detroit, MI
  • Nadir Ahmad
    Department of Otolaryngology-Head & Neck Surgery, Henry Ford Health System, Detroit, MI
  • Michael Seidman
    Department of Otolaryngology-Head & Neck Surgery, Henry Ford Health System, Detroit, MI
Article Information
Hearing Disorders / Mechanisms
Article   |   September 01, 2005
Mechanisms of Ototoxicity
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics, September 2005, Vol. 9, 2-10. doi:10.1044/hhd9.1.2
SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics, September 2005, Vol. 9, 2-10. doi:10.1044/hhd9.1.2
The last century witnessed the unparalleled discovery of pharmacologic agents with both life-saving and quality-enhancing effects. Despite such virtues, the use of these agents also entails the possibility of adverse effects and inner ear (or “oto”) toxicity represents one of these potential complications. Understanding the mechanisms of ototoxicity has proved difficult largely due to the complex interplay between the offending agent and the specific host inner ear milieu. It is also not uncommon to use multiple offending agents in the same clinical setting, which can further complicate the assessment of ototoxicity. Additionally, pre- and post-treatment objective measurements of toxicity are most often difficult to ascertain. Furthermore, microscopic study of specific inner ear injuries requires post-mortem examination. As a result, much of our knowledge is based on animal models, which may not correlate well with human pathology. Nonetheless, certain classes of medications have been shown to be predictably ototoxic in humans. This paper will highlight the commonly known ototoxic agents and will elucidate their mechanisms of causing inner ear pathology and the clinical expression of these processes.
First Page Preview
First page PDF preview
First page PDF preview ×
View Large
Become a SIG Affiliate
Pay Per View
Entire SIG 6 Perspectives on Hearing and Hearing Disorders: Research and Diagnostics content & archive
24-hour access
This Issue
24-hour access
This Article
24-hour access
We've Changed Our Publication Model...
The 19 individual SIG Perspectives publications have been relaunched as the new, all-in-one Perspectives of the ASHA Special Interest Groups.